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cannabis e os espermatozoides

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cannabis e os espermatozoides

Mensagem por pedrix em Sex Ago 07, 2009 9:59 pm

procuro informaçao sobre este assunto,pelo pouco que pesquisei cheguei à conclusao que o thc é um veneno para estas sementes da vida,torna-os completamente imoveis logo inuteis.sou consumidor regularissimo de polen de cannabis e fui confrontado com uns pessimos resultados de um espermograma.
tou a um passo da terrivel,inevitavel e odiada abestinencia Sad


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Re: cannabis e os espermatozoides

Mensagem por jonas84 em Sex Ago 07, 2009 10:12 pm

Bem vindo ao forum Pedrix

Vamos investigar isso, pessoalmente não tenho a informação que precisas mas sei que já li varias coisas sobre o assunto nos fóruns estrangeiros. Depois coloco aqui o que encontrar.

Sei que não tem nada a ver, mas eu sou consumidor regular e é "cada tiro cada melro".

Última edição por jonas84 em Sex Ago 07, 2009 10:20 pm, editado 1 vez(es)

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Re: cannabis e os espermatozoides

Mensagem por jonas84 em Sex Ago 07, 2009 10:19 pm

Encontrei isto em Ingles, Vai ficar em lista de espera para tradução.

A reproductive medicine specialist at the University at Buffalo has
shown that a new compound may improve the fertility of tobacco smokers
who have low sperm count and low percentage sperm motility.

The sperm from male smokers were washed with a synthetic chemical
called AM-1346. After incubation, there was a doubling in the
fertilizing capacity of sperm from poor quality semen, results showed.

Lani Burkman, Ph.D., and colleagues presented the findings at the 2006
meeting of the American Society of Reproductive Medicine held recently
in New Orleans. "Based on our previous data and published literature,
it is clear that most tobacco smokers will exhibit a small or a
significant decline in fertility," she stated. "Nicotine addiction is
quite powerful. The best solution is to stop smoking and then wean
yourself off of all nicotine products. But for smokers who can't quit,
the in vitro use of AM-1346 may significantly improve their fertilizing

Burkman, associate professor in the departments of
gynecology/obstetrics and urology and head of the Section on Andrology
in the UB School of Medicine and Biomedical Sciences, previously
demonstrated that sperm functions critical for fertilization are
altered by nicotine exposure, whether in vitro, or through long-term
tobacco use. Two-thirds of the male smokers studied had decreased
fertility; some showed a serious loss.

The new study involved nine selected smokers (22 experiments) who had
been evaluated previously for sperm fertilizing potential using the
outside cover of a human egg, called the zona pellucida. Four men had a
high number of sperm attaching to the zona (normal, Group I), while
five other smokers had sperm with poor egg binding (poor fertilizing
potential, Group II).

The new experiments were designed to evaluate whether sperm with poor
fertilizing capacity from smokers could be treated so that egg binding
was improved. Specifically, the researchers studied a potential
interaction between two chemical systems that control sperm.

"Human sperm carry the cholinergic receptor, which responds to the
neurotransmitter acetylcholine," noted Burkman. "Nicotine mimics
acetylcholine and binds to the cholinergic receptor." In earlier
research, Burkman and colleagues also showed that human sperm contain
cannabinoid receptors, which respond to marijuana, as well as natural
cannabinoids occurring in the body.

"Research from other scientists indicates that the cholinergic system
and the cannabinoid system naturally regulate human sperm and help
prepare them for fertilizing an egg," she said. "Our research suggests
that this natural regulation is out of balance for the majority of
smokers when sperm are continuously exposed to nicotine.

"We think there is an important communication between the cannabinoid
and cholinergic receptor systems in human sperm," said Burkman. "No one
has shown this interaction before when looking at human tissue.
AM-1346, the drug that we tested, is a synthetic version of a natural
cannabinoid found in the body.

"In 22 Hemizona tests, we showed that the response to AM-1346 depended
on the initial fertility of the tobacco smoker, and if his semen showed
poor quality, meaning low sperm count and low percentage motility."

The sperm from Group II volunteers were incubated with AM-1346 for
several hours and then retested in the Hemizona Assay. Six experiments
in Group II started with semen of low quality and all six resulted in
stimulation of sperm binding to the zona ranging from 133 percent to
330 percent, with a mean of 201 percent, when compared to their own
untreated sperm, results showed.

"In contrast," said Burkman, "samples from Group I (normal fertility,
normal semen quality) reacted in the opposite manner. This two-way, or
biphasic, response is common for cannabinoid action. With Group I, the
drug AM-1346 caused a substantial decrease in sperm binding to the zona
for eight out of nine samples.

"This opposite response must be studied further," Burkman said. "It
might be tied to early-versus-late steps in fertilization, where it is
expected that one process is slowed down while another process is

"It does appear that sperm functioning in tobacco smokers with low
fertility and low semen quality is quite different when compared to
smokers with higher fertility and good semen quality. Nicotine appears
to change the sperm membranes and sperm receptors. It also raises the
question of why sperm from some smokers are protected from the effects
of tobacco and nicotine."

Roxanne Mroz and MaryLou Bodziak, UB research associates, contributed
to this work, along with UB undergraduate students Stuti Tambar and
Brian Telesz. Alexandros Makriyannis, Ph.D., from Northeastern
University, created AM-1346.

The University at Buffalo is a premier research-intensive public
university, the largest and most comprehensive campus in the State
University of New York. The School of Medicine and Biomedical Sciences
is one of five schools that constitute UB's Academic Health Center.

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Re: cannabis e os espermatozoides

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